Spaniard Garbine Muguruza wins French Open Women's singles title
Williams, 34, was trying to win her fourth French Open title and had hoped to win a 22nd Grand Slam singles title and tie Steffi Graf's Open-era record
Spain's Garbine Muguruza beat world number one Serena Williams in straight sets to win her first Grand Slam title at the French Open. In the process, the 22-year-old became the first Spaniard since Sanchez-Vicario to clinch the title at Roland Garros
Fourth seed Muguruza took sweet revenge of last year's loss in the Wimbledon final against Williams by packing off her in two straight sets (7-5 6-4).
Williams, 34, was trying to win her fourth French Open title and had hoped to win a 22nd Grand Slam singles title and tie Steffi Graf's Open-era record.
Williams had reached the final despite struggling with a thigh problem, but the defending champion began in terrific form, moving freely as she made the early running.
Williams looked to have gained the upper hand with three games in a row taking her 5-4 in front.
However, Muguruza played a nerveless service game to stay in the set and then clinched it with some wonderful hitting down both tram lines.
The second set began with three breaks of serve but it was still Muguruza who was dictating, another stunning forehand into the corner moving her into a 3-1 lead.
Williams could not fashion a break point in the latter stages of the second set and did well to fend off four match points on her own serve in game nine.
Muguruza remained rock solid, however, finally converting on her own serve with a lob that caught both players by surprise, before the Spaniard started her celebration.
Williams suffered only her sixth defeat in 27 Grand Slam finals stretching back to 1998, but did not blame her injury issues.